Kotra Research Group


Kotra research group is a multidisciplinary group investigating at the interface of medicinal chemistry, drug design, drug targets, preformulations and drug lead development. Kotra laboratory is licensed by Health Canada to conduct research with specific controlled drug substances including medical cannabis.

The group transcends various silo disciplinary barriers in pharmaceutical sciences to advance the knowledge from the understanding of biological mechanisms through the design of probe molecules, development of “drug-like” lead compounds, to achieve pharmaceutical products. Kotra group works with collaborators within University Health Network, University of Toronto as well as from other universities and pharmaceutical companies.

Current research interests include developing molecular design strategies targeting infectious diseases (malaria, antivirals), diabetic neuropathy, neuropathic pain, multiple sclerosis and Alzheimer's disease. In this effort, we employ a variety of chemical expertise, including organic synthesis, medicinal chemistry, bioanalytical chemistry, preformulations, drug delivery, natural products extraction and analyses.

The lab is located in the heart of Toronto at 101 College Street, in the Toronto Medical Discoveries Tower of the MaRS Center.

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Kotra group is a multi-disciplinary team, grounded in medicinal chemistry with expertise in computer modeling, in vitro and in vivo models of disease, leading to preclinical drug discovery and development. Investigations on drug targets of disease significance, biochemical mechanisms, biomarkers for animal models of diseases are a part of keen interest, along with the design of novel ligands and evaluation of small molecule ligands for drug development. Group members enjoy a very intensive, highly-integrated team environment with a goal to be highly competitive internationally. Please see Publications section for latest publications from our group.

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Kotra group enjoys access to state-of-the-art instrumentation and facilities for medicinal chemistry/drug discovery research at University Health Network (Toronto, Canada) at the University of Toronto (Canada).

To arrange for a visit to the laboratory, please contact Dr. Kotra: lkotra@uhnresearch.ca

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Kotra Research Group

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